Social Support and Dopamine Receptors (significant to everything we do on this site)

Submitted by gary on
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NOTE: Below is a very significant study.
In general, low density of dopamine receptors are associated with addictions, cravings, ADD, drug and orgasm hangovers, depression, social anxiety, and so much more. High density of dopamine receptors are associated with feeling good, positive attitude, less desire for mood altering experiences/drugs, joy in the little things, etc.

For me, the take away from this human study is that social support is associated with increased density of dopamine receptors. Whether it's 12-step groups, love of friends, partner (or dog), interacting on this forum, or having a courtly companion, they all lead to the changing of our brains.

Put simply, our reward circuits are growing more and more dopamine receptors as we continue to get and give support. As time goes on (and dopamine receptors increase), we become less vulnerable to addictions, better able to handle the lows, or the adversities. We bounce back quicker. We have motivation for new things. We find more joy in everyday activities. Even our partner starts to look cuter.

BRAIN DOPAMINE RECEPTOR DENSITY CORRELATES WITH SOCIAL STATUS

ScienceDaily (Feb. 3, 2010)
People have typically viewed the benefits that accrue with social status primarily from the perspective of external rewards. A new paper in the February 1st issue of Biological Psychiatry, published by Elsevier suggests that there are internal rewards as well.

Dr. Martinez and colleagues found that increased social status and increased social support correlated with the density of dopamine D2/D3 receptors in the striatum, a region of the brain that plays a central role in reward and motivation, where dopamine plays a critical role in both of these behavioral processes.

The researchers looked at social status and social support in normal healthy volunteers who were scanned using positron emission tomography (PET), a technology that allowed them to image dopamine type 2 receptors in the brain.

This data suggests that people who achieve greater social status are more likely to be able to experience life as rewarding and stimulating because they have more targets for dopamine to act upon within the striatum.

Dr. Martinez explains their findings: ."We showed that low levels of dopamine receptors were associated with low social status and that high levels of dopamine receptors were associated with higher social status. The same type of association was seen with the volunteer's reports of social support they experience from their friends, family, or significant other.".

Dr. John Krystal, Editor of Biological Psychiatry commented, "These data shed interesting light into the drive to achieve social status, a basic social process. It would make sense that people who had higher levels of D2 receptors, i.e., were more highly motivated and engaged by social situations, would be high achievers and would have higher levels of social support."

These data also may have implications for understanding the vulnerability to alcohol and substance abuse, as the work of Dr. Nora Volkow, the Director of the National Institute on Drug Abuse, and colleagues suggests that low levels of D2/D3 receptors may contribute to the risk for alcoholism among individuals who have family members who abuse alcohol. The current data suggest that vulnerable individuals with low D2/D3 receptors may be vulnerable to lower social status and social supports, and these social factors have previously been suggested as contributors to the risk for alcohol and substance use.

These findings are particularly exciting because they put human neurobiology into a social context, and we humans are fundamentally social creatures. It is in these social contexts that the biological effects on behavior obtain their real meaning.

Comments

you are absolutely right

The most obvious interpretation is that those with high density of dopamine receptors are higher on the scale of - cheerful, outgoing, motivated, and so on. Therefore, they are more attarctive to be around and tend to seek out relationships. As a result, they end up with more friends, social opportunities, work opportunities, etc.
I think this is true.

Another question is: Within what limits can dopamine density be altered?
Which leads to the next question: For any individual, what are the genetics of my D2/D3 receptors? Am I toward the low end, or the high end? (and what role does genetics play).

The next question is what developmental factors (stressed mom, bad diet, metallica instead of mozart) was I exposed as I grew inside mommy? As we know, everything about our anatomy and physiology is both genetics and environment continuously interracting, and to a point malleable.

But the important question is: Can I alter my dopamine density? The answer is yes. On the downside, take drugs and dopamine receptors decrease. That is the major cause of addiction.
But can we increase them? Get off drugs and they come back.

I believe that we can also increase dopamine and increase dopamine receptors through behaviors: exercise, meditation, social interraction, maybe falling in love. For me, Karezza and avoiding orgasm has made a huge difference. I have always known that I have low dopamine receptors levels. My mother was depressed and an alcoholic. I followed in her foot steps. I was depressed for as long as I remember. As a teen I played basketball for hours on end, just to feel good.

When I met Marnia, I was 5 years on antidepressants, and addicted.
Over time my brain changed. Today I have no depression, for the first time in my life. I got to observe the changes, and what happened to me when I had an accidental orgasm.
The combination of daily bonding behaviors and avoiding orgasm has altered my reward circuitry - I just know it. Need both.

So - are my upper limits of dopamine receptor levels constrained by my particular biology? Probably. But I can do things to keep them in the high range - that is, the high range for me.

I think the study describes

I think the study describes me and what I am experiencing very well. The more a interact here and with my new friend and her support the more things change for me. I have found it easier and easier to keep control of my addiction also I was able to pull myself out of this latest relapse a lot easier than I would have thought. Also it was not a full relapse to everything like I feared. So I have gained more control.
The other thing is I am seeking new things. I am seeking new social status. I have started actively talking about addiction and how the reward circuitry works to people at work and home. I have started my plans to go back to school. I want to very much now. It is like a driving force to get back into school. I started with the thought of going back this coming fall. Now today I shifted and I want to start this summer. I am shifting fairly fast On some things right now. I know all this support and interaction is changing me. Changing my perception of things. The world has not changed but I have. I have changed I think much like this study talks about. I think I am developing more receptors. Cause I am getting more motivated. Things are shifting rapidly I am not sure how much I will change but my changing has not slowed down yet and I think it is increasing. Right now just talking about it makes me want to get started in school. I want more. One bad side effect of this is I am growing to dislike my job. 6 months ago I was happy with it even though it was a dead end job and I would never advance further in it than I am now. I was just "happy" to continue my porn addiction and stay in the job I was at and I was ok with being at that state and staying there. Well now the job is driving me crazy. I just need to do something else. I have to work at calming myself. I need to keep my job lol. I need to keep it till I get through with school but now it is going to be tough. Not sure how to handle it. Maybe I will come up with something as time goes by. I think I am getting hyper motivated in some areas. If this kicks in across the board it will be great if a bit scary at first and to think about. I guess it is a kind of addiction itself only more "healthy" although I can see it getting out of hand if you let it. It is that more more more attitude. You always need to find balance in everything you do I guess :)
Some thoughts and ramblings
Great article
Thanks

What about oxytocin?

Sometimes on this site, and in the press, dopamine and oxytocin get labels - such as:
Dopamine: craving, lust, addictions, wanting
Oxytocin: love, friendship, bonding, giving

The above labels are helpful in understanding some basics, but tend create a lot of misconceptions.

What do love, friendship, bonding, giving, OR craving, lust, addictions, wanting, all have in common? Activation of the reward circuitry (links at bottom).

Love, sexual desire, erections, friendships, caring, and bonding with anyone or anything, involve BOTH oxytocin and dopamine acting on very specific pathways within the reward circuit.

With oxytocin and dopamine, one's experiences depend on:

1) levels of each neurochemical
2) what receptors each binds to
3) what sections of the reward circuitry each one activates

Example: Love for your sexual partner; Love for your child. These two "loves" involve both oxytocin and dopamine being released, and turning on parts of the reward circuit. Most sections being activated overlap. However some do not. Which sections do not overlap determine the differences between romantic and parental love....or dog love.

Another example: Drugs - all addictive drugs activate the reward circuitry, and increase dopamine, yet they all have unique highs. Caffeine is experienced quite differently from alcohol, yet both jack up dopamine. The difference in the experience comes down to slightly different aspects of the reward circuit being turned on.

Interestingly, alcohol appears to increase oxytocin a bit, while the drug ecstasy makes oxytocin soar.

It's like these neurochemicals are ingredients in a recipe for a cake (cake representing reward, appropriately). All cakes need flour, or dopamine for reward activation. But the other ingredients can vary - and changing a recipe equals a slightly different cake, or in this a rewarding experience.

Key point: We need both dopamine and oxytocin activated, in the reward circuit for: Bonding, love, friendships, caring - and all the associated feelings. In science-speak, these interactions are rewarding.

There's much still to learn, but it appears that oxytocin does a lot of its magic (love, friendships) through increasing dopamine. Oxytocin appears to make a particular person rewarding - through increasing dopamine whenever you interact with, or think about, that person.

So when dopamine receptor density is low, or dopamine is reduced, activation of the reward circuit is reduced. And your partner can look like cold oatmeal...to you.

http://thebrain.mcgill.ca/flash/i/i_03/i_03_cl/i_03_cl_que/i_03_cl_que.html
http://thebrain.mcgill.ca/flash/i/i_03/i_03_cr/i_03_cr_que/i_03_cr_que.html